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Since inhibition of FXR in intestinal L cells is able to promote GLP-1 release 11 , changes in BA composition or profiles are likely to affect glucose homeostasis by controlling insulin secretion via modulating GLP-1 production
One retreatment: Patients receive 1 additional course of semaglutide following an off-treatment period
doi: 10.3389/fphar.2014.00196 Received 05 July 2014 Accepted 06 August 2014 Published 26 August 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Anastassios Papageorgiou, University of Turku, Finland
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In the CNS, GLP-1 also exert neuroprotective and neurotropic effects by binding to GLP-1R (116)
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